Cefazolin IMpurity E
2-Mercapto-5-methyl-1,3,4-thiadiazole
CAS: 29490-19-5
Molecular Formula: C3H4N2S2
Cefazolin IMpurity E - Names and Identifiers
Cefazolin IMpurity E - Physico-chemical Properties
| Molecular Formula | C3H4N2S2 |
| Molar Mass | 132.21 |
| Density | 1.373 (estimate) |
| Melting Point | 185-188 °C |
| Boling Point | 182.9±23.0 °C(Predicted) |
| Flash Point | 64.4°C |
| Water Solubility | 2 g/100 mL |
| Solubility | chloroform: soluble10mg/mL, clear to very slightly hazy, colorless |
| Vapor Presure | 0.791mmHg at 25°C |
| Appearance | White to bright milky white powder |
| Color | White to Off-White |
| BRN | 606663 |
| pKa | 6.49±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5500 (estimate) |
| MDL | MFCD00038349 |
| Physical and Chemical Properties | White crystalline powder. Melting point 184 °c. |
| Use | Mainly used as an intermediate of cefazolin sodium |
Cefazolin IMpurity E - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Hazard Note | Irritant |
Cefazolin IMpurity E - Nature
Open Data Verified Data
white crystals. The melting point was 174-175 °c. Soluble in hot water, soluble in ethanol.
Last Update：2024-01-02 23:10:35
Cefazolin IMpurity E - Preparation Method
Open Data Verified Data
ethyl acetate method, thioacetamide method.
- The ethyl acetate method is obtained by reacting with hydrazine hydrate and then heating and cyclizing.
- thioacetamide method each example: 112g of thioacetamide was dissolved in of dimethylformamide, and G of hydrazine hydrate was added dropwise at a temperature of 10 ° C. Or lower. 137g of carbon disulfide was then added dropwise to th at a temperature below 10 °c. th was then stirred at 35 °c. The reaction solution was gradually heated to 100 ° C., and the hydrogen sulfide was driven out until no hydrogen sulfide occurred. Then, of dimethylformamide was distilled off under reduced pressure. The concentrated reaction solution was added with 250ml of water and cooled to 20 °c. The precipitated crystals were filtered, washed with water, and dried to obtain 169g of product with a yield of 85.4% and a content of 99.7%.
Last Update：2022-01-01 10:57:44
Cefazolin IMpurity E - Introduction
Soluble in hot water, soluble in ethanol
Last Update：2022-10-16 17:24:20
Cefazolin IMpurity E - Application
Open Data Verified Data
is the raw material of cefazolin, cefoxitin, and azolone cephalosporin.
Last Update：2025-08-19 16:24:40
Cefazolin IMpurity E - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| use | this product is an intermediate of antibiotic drug cephalosporin v mainly used as an intermediate of cefazolin sodium used as a pharmaceutical intermediate mainly used as an intermediate of cefazolin sodium (pioneer 5). |
| Production method | It is obtained by hydrazinization, addition, and cyclization of ethyl acetate. Ethyl acetate, hydrazine hydrate and anhydrous ethanol were heated and refluxed for 5h to obtain acetylhydrazine ethanol solution. Then it is cooled. Add carbon disulfide and stir at 25 ℃ for 1h. Then cooled, let stand and filtered. The filter cake was washed with absolute ethanol to obtain potassium N-acetylhydrazinyl dithioformate. After low-temperature drying, it is added to concentrated acid below -5°C in stages, and stirred at a temperature not exceeding 5°C. Then the reactants are frozen and filtered. The filter cake is washed with a large amount of ice water to remove the free sulfuric acid, and then dried under low temperature vacuum to obtain thiadiazole. |
Last Update：2024-04-10 22:29:15
Supplier List
Featured ProductsSpot supply
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole (MMTD) Visit Supplier Webpage Request for quotationCAS: 29490-19-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole Request for quotationCAS: 29490-19-5
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole Request for quotation
CAS: 29490-19-5
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 29490-19-5
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: Cefazolin EP impurity E Request for quotationCAS: 29490-19-5
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole Request for quotationCAS: 29490-19-5
Tel: +86-17505207175
Email: 3787852685@qq.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Spot supply
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole Request for quotationCAS: 29490-19-5
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole Request for quotation
CAS: 29490-19-5
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
CAS: 29490-19-5
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Spot supply
Product Name: 5-Methyl-1,3,4-thiadiazole-2-thiol Request for quotationCAS: 29490-19-5
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole (MMTD) Visit Supplier Webpage Request for quotationCAS: 29490-19-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 5-Methyl-1,3,4-thiadiazole-2(3H)-thione (Standard) Visit Supplier Webpage Request for quotationCAS: 29490-19-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Featured ProductsSpot supply
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole (MMTD) Visit Supplier Webpage Request for quotationCAS: 29490-19-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole Request for quotationCAS: 29490-19-5
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole Request for quotation
CAS: 29490-19-5
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 29490-19-5
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: Cefazolin EP impurity E Request for quotationCAS: 29490-19-5
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole Request for quotationCAS: 29490-19-5
Tel: +86-17505207175
Email: 3787852685@qq.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Spot supply
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole Request for quotationCAS: 29490-19-5
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole Request for quotation
CAS: 29490-19-5
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
CAS: 29490-19-5
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Spot supply
Product Name: 5-Methyl-1,3,4-thiadiazole-2-thiol Request for quotationCAS: 29490-19-5
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 2-Mercapto-5-methyl-1,3,4-thiadiazole (MMTD) Visit Supplier Webpage Request for quotationCAS: 29490-19-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 5-Methyl-1,3,4-thiadiazole-2(3H)-thione (Standard) Visit Supplier Webpage Request for quotationCAS: 29490-19-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
View History
Cefazolin IMpurity E
5-Formylisothiazole
Acetyl tetrapeptide-3
(2-methoxyethoxy)benzene
3,4-DIFLUOROCINNAMIC ACID
3653-05-2
102735-84-2
105-44-2
5910-87-2
124-38-9
5-Formylisothiazole
Acetyl tetrapeptide-3
(2-methoxyethoxy)benzene
3,4-DIFLUOROCINNAMIC ACID
3653-05-2
102735-84-2
105-44-2
5910-87-2
124-38-9